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This white paper is available as a PDF PREPARATION
AND USE OF CORONAVIRUS DISINFECTANTS The
following information is based on the scientific literature and
leading authorities such as the World Health Organization (WHO) and
the China and US Center for Disease Control (CDC). With anticipated
shortages of sanitizing agents we provide instructions for the
preparation and use of disinfectant solutions that are effective at
killing the Coronavirus. Suggested
use of the disinfectants are described below. Links
are also provided for the source literature.
Grocery or Shopping Stores may not have
sufficient sanitary wipes. Additionally,
wiping down a grocery cart is not practical. The method described
below takes less than 30 seconds and helps reduce viral load that
could be transferred to you or your groceries.
Disinfecting
Groceries Do not bring grocery
bags into home before disinfecting. Instead
treat as described below.
NOTE:
Redundant non-refrigerated supplies not needed for more than one
week can be stored in an unprocessed state in low traffic areas like
a garage, attic, cellar, or wash room as the virus will die
naturally at ambient temperatures. Packages and Mail Covid-19 surface
survival time can last days. Per the US or China CDC this mode of
transfer is currently not alerted but in our modern era of overnight
shipping it is critical all packages get wiped down as described for
groceries before bringing into the home. Other
NOTE- Freezer and cold
storage will preserve virus so it is important to disinfect before
putting items into any type of cold storage PREPARATION OF
DISINFECTANT SOLUTIONS Commercial rubbing
alcohol, e.g, isopropyl alcohol, isopropanol, sold as a 70% solution
in water, is the recommended concentration to use as a disinfectant
and can used ‘as is’. For 99.9% or 90% isopropyl alcohol we
provide dilution recipes below to achieve the desired target
concentration of 70%. If isopropanol becomes unavailable ethanol
(grain alcohol) may be substituted. A bleach solution preparation is
also described which is practical for ‘dipping’ items to
disinfect. The WHO recommended hand sanitizing recipe is also
provided. Isopropanol or Ethanol Solutions If only 99.9% (pure)
isopropanol or ethanol is available you can prepare a 70% alcohol
solution as described below. If using ethanol / grain alcohol (200
proof) a 70% solution would be 140 proof so 'no' your Titos vodka
(40% alcohol. 80 proof) or Wild Turkey 101 (50% alcohol) won’t be
effective. Besides even
the Coronavirus does not deserve our sacred preserves. Directions to
Prepare a 70% Alcohol Solution Using 99.9% Isopropyl Alcohol: Measure 350 mL alcohol
in a measuring cup and pour into a container. Measure 150 mL of
water and add to the measured isopropanol and mix. Adjust the volume
by adding more water as necessary to achieve a final volume of 500
mL. NOTE: Alcohol and water are ‘non ideal’ solutions. If you mix 1 part water with 1 part alcohol you don’t end up with 2 parts total! Thus in our procedure above you will end up with about 480 mL after combining the 350 mL alcohol and 150 mL water thus the need to make the final adjustment to achieve the final 500 mL target volume. Diluting 90-91%
Isopropyl Alcohol to achieve a 70% solution: To achieve a 70%
solution using 90-91% input isopropanol add about 400 mL of water to
2 liters of alcohol and you will end up with something 2.5 liters of
70% isopropanol. Bleach Solutions Commercial
Bleach and Water Directions to
Prepare a Bleach Solution: Mix ⅓ cup bleach
per 1 gallon of water or 4 teaspoons bleach per 1 quart of water or
1 part to 25 parts water is effective in killing virus albite longer
times required up to 10 minutes. Bleach solutions in water
compliment alcohol solutions and can be used to dip produce and
other items for disinfecting prior to bringing into home. The WHO Hand Sanitizing Solution Isopropyl
Alcohol, Hydrogen Peroxide, Water, and Glycerol This solution can also
be used in spray bottles. Directions to
Prepare the WHO Hand Disinfectant Solution: The
WHO procedure utilizes either pure ethanol (grain alcohol) or pure
isopropyl alcohol. Procedures below have been adjusted to allow for
use of more common 70% or 90% isopropyl alcohol if 99.9% not
available. Use
of 100% Ethanol:
Use
of 100% Isopropyl Alcohol:
Use of 70% Isopropyl Alcohol
Use
of 90% Isopropyl Alcohol:
Other
Available Household Agents A
link is provided to an EPA listing of common household agents that
are proven effective against the coronavirus. While not included
common house hold cleaners such as Windex, glass cleaners, and
ammonia based cleaners will also be effective. Masks A
Tweet from our surgeon general states masks are not effective in
preventing transmission of the Coronavirus. For the record this is
insulting to basic intelligence and scientific principles. OF
COURSE masks prevent transmission. The truth is that America does
not have enough masks thus instead of telling the truth our own
leaders try to convince us that masks are magically only effective
for health care workers. Read the China CDC website yourself
referenced below where ‘policy’ requires all citizens not to
leave your home without donning of a mask.
USEFUL
REFERENCES AND LINKS WHO Hand sanitizer: https://www.who.int/gpsc/5may/Guide_to_Local_Production.pdf EPA Tested House
hold / commercial antiviral products; https://www.epa.gov/pesticide-registration/list-n-disinfectants-use-against-sars-cov-2 Persistence of
coronaviruses on inanimate surfaces and their inactivation with
biocidal agents: USA CDC
“Coronavirus Disease 2019 (COVID-19): China CDC
“Covid-19 Prevention and Control: Effectiveness of
common household cleaning agents in reducing the viability of human
Influenza A/H1N1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813869/ About
the Author:
+1
919 571 8037 mandersen@TriphasePharmaSolutions.com
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Marc
W. Andersen, Ph.D., RAC, President of TRIPHASE® Pharma Solutions.
LLC, manages drug development programs for FDA approval of diverse
therapeutic agents including antiviral agents and manufacture of
sterile products.
